intrinsic signals that regulate adult neurogenesis in vivo Biology Diagrams For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the mol โฆ
The advances presented by Pechnick et al. broaden the focus to urge further elucidation of cell cycle and its regulators in adult neurogenesis. Because cell cycle regulators, including p21, also control proliferation and survival of brain tumor stem cells, attempts to consider such regulators as "druggable" therapeutic targets require a
Neurogenesis and the Cell Cycle Biology Diagrams
Keywords: Cell cycle, Differentiation, Neurogenesis, Proneural, Central nervous system. Introduction. During development of the central nervous system (CNS), a period of extensive proliferation is needed to generate the required number of progenitor cells for correct tissue and organ formation. This must be accompanied or closely followed by Once neurogenesis is complete, mature neurons do not divide. Herrup and Yang outline the evidence that, in order to achieve this, adult neurons must constantly hold their cell cycle in check, and
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J. Cell Sci. 116, 4947-4955 (2003).
Cell cycle regulation, neurogenesis, and depression Biology Diagrams
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis Development . 2011 Oct;138(19):4267-77. doi: 10.1242/dev.067900.
The adult neurogenesis in adult dentate gyrus has been divided into different developmental stages in which quiescent neural stem cells enter into the cell cycle (type 1 NSCs) and give rise to postmitotic neurons through three consecutive stages of intermediate progenitor cells (type-2ab) and neuroblasts (type-3), which migrate within the
